The woman who trained Ed and Al in the art of alchemy and drove the concept of "Equivalent Exchage" into their heads with her philosophy of "One is All, All is One"
Prone to angry outburst when called "Old" or "Hag". Suffers from bouts of blood vomiting due to her losing portions of her internal organs when she attempted to transmute her dead baby.
In the 2003 anime, her transmutation gives birth to the child like homunculus "Wrath".